144528-06-3

Upstream product

• 934-32-7 1H-benzimidazol-2-amine 
• 89-95-2 2-methyl-benzyl alcohol 
• 90-02-8 salicylaldehyde 

Downstream Products

• 565450-12-6 Gd(N-salicylidene-2-aminobenzimidazole)Cl(H₂O) 
• 565450-13-7 Yb(N-salicylidene-2-aminobenzimidazole)Cl(H₂O) 
• 565450-10-4 Pr(N-salicylidene-2-aminobenzimidazole)2(H₂O) 
• 565450-11-5 Nd(N-salicylidene-2-aminobenzimidazole)Cl(H₂O) 
• 1589490-14-1 trans-[RuCl(bzp)(PPh₃)₂] 
• 364599-60-0 2-[(2'-hydroxybenzyl)amino]benzimidazole 
• 1383854-96-3 CH₄O*C₁₄H₁₃N₃O*H₃O₄P 
• 1383854-98-5 C₃H₇NO*C₇H₄N₂O₆*C₁₄H₁₃N₃O 
• 1383854-94-1 C₂H₄O₂*C₁₄H₁₃N₃O 
• 1383854-93-0 C₁₄H₁₃N₃O*HNO₃ 

Relevant academic research and scientific papers

Discrete tetrairon(III) cluster exhibiting a square-planar Fe 4(μ4-O) Core: Structural and magnetic properties

The aerobic reaction of the Schiff-base ligand N-(benzimidazol-2-yl) salicylaldimine (Hbisi) with iron(II) Perchlorate in methanol leads to the formation of the remarkable coordination compound [Fe4(μ 4-O)(μ-MeO)4(bisi)4]-(ClO4) 2·4MeOH (1), whose single-crystal X-ray structure reveals the presence of a discrete Fe4(μ4-O) core. Magnetic and Moessbauer studies both show that the exchange interaction within the square tetranuclear iron(III) unit is dominated by the central bridging μ4-oxido ligand, the involvement of the ,μ-methoxido bridges being negligible.

Coordination induced monolayer formation and fabrication of a novel conductive Langmuir-Schaefer film of benzimidazole-containing Schiff bases without a substituted alkyl chain

Two benzimidazole-containing Schiff bases: 2-[(2'-hydroxybenzylidene)amino]benzimidazole (HBA) and 2-[(2'-hydroxynaphthylmethylidene)amino]benzimidazole (HNA), which have no substituted long alkyl chain, have been found to form stable monolayers at the air-water interface when Ag(I) ions are present in the subphase. The monolayers can be further transferred onto solid substrates using the horizontal lifting method. The transferred films were characterized by UV-Vis absorption, X-ray photoelectron spectra (XPS) and X-ray diffraction. It has been found that monolayers were formed through the coordination between the benzimidazole moiety and Ag(I) ions. The transferred Langmuir-Schaefer (LS) films thus formed showed a relatively large conductivity in the oredr of 10-1Scm-1. In addition, photoirradiation upon the film can cause a change in the conductivity.

Facile one-pot synthesis of novel: N -benzimidazolyl-α-arylnitrones catalyzed by salts of transition metals

A novel series of N-benzimidazol-2-yl-α-aryl nitrones 3a-j is synthesized via simple one-pot condensation/oxidation of 2-aminobenzimidazole, an aromatic aldehyde and m-chloro perbenzoic acid (m-CPBA) as an effective oxidant using Mn(NO3)2

Synthesis, characterization and antiamoebic activity of benzimidazole derivatives and their vanadium and molybdenum complexes

Reaction of [MoO2(acac)2] (where, acac=acetyl acetone) and KVO3 with 2-(salicylidieneimine) benzimidazole lead to form new complexes [MoO2(sal-BMZ)2] and K [VO2(sal-BMZ)2] [where

A benzimidazole-based Co3+ complex for electrochemical and spectroscopic recognition of I- and HSO4- in semi-aqueous media

A benzimidazole-based Co3+ complex was synthesized and evaluated as a sensor for I- and HSO4- in aqueous media. The complex showed electrochemical changes with I- over other anions, whereas it had a ratiometric response to HSO4- with UV-visible spectroscopy even in the presence of other anions.

A highly selective chemosensor for Al(III) and Zn(II) and its coordination with metal ions

This paper reports a fluorescence chemosensor, N-(benzimidazol-2-yl) salicylaldimine (H2L), for Zn(II) and Al(III) ions. H2L has high selectivity for Al(III) in dimethyl sulfoxide (DMSO) and for Zn(II) in N,N-dimethylformamide (DMF). In methanol, Zn(II) and Al(III) could also be distinguished by H2L with different excitation wavelengths. The fluorescent species [Zn(HL)(H2O)(CH3OH)]+, [Zn(HL)(H2O)(DMF)]+, [Al(HL)2(OH)(H 2O)], and [Al(HL)(OH)2(H2O)(DMSO)] formed in solution were established by a combination of experimental and theoretical methods, including Job's plot, 1H NMR titration, electrospray inonization mass spectrometry (ESI-MS), and B3LYP-SCRF/6-31(d) and TD-B3LYP-SCRF/6-31G* density functional theory methods. The results show that Zn(II) and Al(III) are all coordinated to the imine nitrogen atom and the hydroxyl oxygen atom from H2L, which is the same as the M 2+ ions in the obtained mononuclear complexes [M(HL) 2(CH3OH)2] (where M = Cd, Ni, Co, and Mg). The detection limits of H2L for Zn(II) were 5.98 μM in methanol and 5.76 μM in DMF, while the detection limits of H2L for Al(III) were 3.3 μM in methanol and 5.25 μM in DMSO. Furthermore, it is also confirmed that H2L has low toxicity for HeLa cells and could be used to detect Zn(II) and Al(III) ions in living cells by bioimaging.

Synthesis and in vitro antiproliferative activity of novel 2-arylideneaminobenzimidazole derivatives

A new class of Mannich bases 9-26, derivatives of 2-amino-1H-benzimidazole, were obtained in the condensation of Schiff bases 1-4 or 2-benzylaminobenzimidazoles 5-8 with selected secondary amines: morpholine, piperidine, N-methylpiperazine, N-phenylpiperazine, 1-(2-pyridyl)piperazine, 1(2-methoxyphenyl)piperazine, 1-(2-pyrimidinyl)piperazine and formaldehyde in ethanol. The pyrimido[1,2-a]benzimidazole derivatives 27-29 have been synthesized in the reactions of Schiff base 2 with selected compounds containing active methylene group: acetylacetone, benzoylacetone and malononitrile. The structures 1-29 were confirmed by the results of elementary analysis and their IR, 1H- and 13C-NMR spectra. The products 1-29 are of interest for biological studies and can be substrates for further synthesis. All compounds were screened against the cells of MV4-11 human leukemia and then the most active of them 5, 7, 9-16, 24-26, 28, 29 were tested towards human T47D breast and A549 lung cancer cells as well as normal mouse fibroblasts (BALB/3T3). The most active compound against the cancer cell lines was 4-amino-3-cyano-2-(4-hydroxyphenylene)-1,2-dihydropyrimido[1,2-a]benzimidazole (29) (IC50 0.23 ± 0.05 μg/mL against MV4-11 cells) showing in parallel very low cytotoxicity towards mouse fibroblasts. Cisplatin was the control drug.

Ruthenium complexes with Schiff base ligands containing benz(othiazole/imidazole) moieties: Structural, electron spin resonance and electrochemistry studies

Novel ruthenium(II/III) complexes of Schiff bases containing benzimidazole (bz) or benzothiazole (bs) moieties were isolated: the diamagnetic ruthenium complex, cis-[RuIICl2(bzpy)(PPh3)2] (1) was formed from the

An efficient synthesis of schiff bases containing benzimidazole moiety catalyzed by bismuth trichloride under microwave irradiation

A simple and efficient method has been developed for the synthesis of some novel Schiff bases via the reaction of aromatic aldehydes with 2-aminobenzimidazole by using catalytic amount of BiCl3 in an organic solvent under microwave irradiation.

Charge-assisted complexation of anions of different dimensionality by benzimidazole-based receptors bearing -OH functionality

Two benzimidazole-based receptors (L1 and L2) bearing -OH functionality form crystalline salts with different organic and inorganic acids viz. [L1H+][Cl-] (1), [L 1H+][NO3-] (2), [L1H +][OAc-] (3), [L1H+][DNB -]DMF (4), [L1H+][H2PO 4-] (5), [L2H+][OAc-]AcOH (6), [L2H+][DNB-] (7), and [L 2H+][HSO4-]H2O (8) where the shape of the counteranion drives the solid structure from a one-dimensional polymeric chain to a three-dimensional structure. Structural analyses show that the anion binding in all eight complexes is attributable entirely to NH +anion, NHanion, OHanion, and multiple CHanion hydrogen bonding interactions. In the solid structure the planar nitrate anion forms a cyclic structure with receptor L1, whereas the acetate anion with the same receptor leads to a molecular barrel type structure. Again the tetrahedral dihydrogen phosphate anion forms a polymeric interanionic chain structure with L1, and the other tetrahedral hydrogen sulfate anion forms hydrogen sulfate-(water)2-hydrogen sulfate adducts with charged L2.