1445582-70-6

Basic information

• Product Name: tert-butyl 2-((3S,4R,5S)-4-benzoyl-4-cyano-5-(4-nitrophenyl)tetrahydrothiophen-3-yl)acetate
• CAS NO: 1445582-70-6
• Molecular Weight: 452.531
• Mol File: 1445582-70-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-((3S,4R,5S)-4-benzoyl-4-cyano-5-(4-nitrophenyl)tetrahydrothiophen-3-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-((3S,4R,5S)-4-benzoyl-4-cyano-5-(4-nitrophenyl)tetrahydrothiophen-3-yl)acetate(1445582-70-6)
• EPA Substance Registry System: tert-butyl 2-((3S,4R,5S)-4-benzoyl-4-cyano-5-(4-nitrophenyl)tetrahydrothiophen-3-yl)acetate(1445582-70-6)

Safety Data

• Hazardous Substances Data: 1445582-70-6(Hazardous Substances Data)

Upstream product

• 61222-95-5 2-Benzoyl-3-(4-nitrophenyl)-2-propenenitrile 
• 109202-02-0 (E)-3-mercapto-2-butenoic acid tert-butyl ester 

Relevant articles and documents

Asymmetric synthesis of trisubstituted tetrahydrothiophenes bearing a quaternary stereocenter via double michael reaction involving dynamic kinetic resolution

The stereoselective synthesis of highly functionalized tetrahydrothiophenes bearing three contiguous stereocenters, one of them quaternary, can be achieved by reacting trans-α-cyano-α,β-unsaturated ketones and trans-tert-butyl 4-mercapto-2-butenoate in the presence of a readily available amine thiourea. The products are obtained in high yield, good diastereoselectivity, and excellent enantioselectivity. The overall formation of tetrahydrothiophenes occurs via a cascade double Michael reaction involving a highly efficient process of dynamic kinetic resolution.