1445684-99-0

Basic information

• Product Name: 4-Chluoro-2-bromotoluene
• Synonyms: Canthaxanthin Beadlet 10% CWS-S;Canthaxanthin Beadlet 10% TAB;CarolGold;CarolGold (Lutein) EMulsion;CarolGold (Lutein) Powder;CarolGold (Lutein);CarolGold (Lutein) Oil Suspension;CarolZea (Zeaxanthin)
• CAS NO: 1445684-99-0
• Molecular Formula: C8H8F3NS
• Molecular Weight: 207.2160296
• Product Categories: Extracted from Marigold;Antifungal;Plant extract
• Mol File: 1445684-99-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Chluoro-2-bromotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chluoro-2-bromotoluene(1445684-99-0)
• EPA Substance Registry System: 4-Chluoro-2-bromotoluene(1445684-99-0)

Safety Data

• Hazardous Substances Data: 1445684-99-0(Hazardous Substances Data)

Usage

Uses

3-((2,2,2-trifluoroethyl)thio)aniline can be used as an intermediate in pharmaceutical research.

Synthesis

To a solution of 3-aminobenzenethiol (4.43 g, 35.4 mmol) in THF (225 mL) was added sodium hydride (1.77 g, 44.3 mmol) at 0 °C and stirred for 30 min. Then, 2,2,2-trifluoroethyl 4- methylbenzenesulfonate (9.0 g, 35.4 mmol) was added and the reaction mixture was stirred for 18 h. The reaction mixture was quenched with water (20 mL) and extracted with EtOAc (2x50 mL). The combined organic extracts were washed with water, dried over Na2SO4, fdtered, and concentrated under reduced pressure. The crude residue was purified by flash chromatography through a Redi-Sep pre-packed silica gel column, eluting with a gradient of 5 % to 10 % EtOAc in hexanes, to give 3-((2,2,2- trifluoroethyl)thio)aniline (5 g, 68 % yield) as a pale brown oil.

Upstream product

• 22948-02-3 3-aminothiophenol 
• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 

Relevant articles and documents

KIF18A INHIBITORS

Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

SUBSTITUTED PHENYLPIPERAZINE COMPOUND AND PEST CONTROL AGENT

PROBLEM TO BE SOLVED: To provide a pest control agent for controlling harmful organisms in agricultural and horticultural fields or harmful organisms to an animal such as a pet and a domestic animal or a domestic animal. SOLUTION: There is provided a substituted phenyl-piperazine compound represented by the following formula (1) or a salt thereof. (wherein, A represents an alkyl group having 1 to 20 carbon atoms which may be substituted or the like; R represents an alkyl group having 1 to 20 carbon atoms which may be substituted or the like; X represents an alkyl having 1 to 6 carbon atoms which may be substituted with a halogen atom, a cyano group or the like; Y represents a halogen atom and an alkyl group having 1 to 6 carbon atoms which may be substituted; m represents any one of integers of 0 to 4; n represents any one of integers of 0 to 8; p represents any one of integers of 0 to 2; and q and r represent any one of integers of 0 to 1.) COPYRIGHT: (C)2015,JPO&INPIT