1445778-72-2

Upstream product

• 4027-57-0 ethyl 5-methyl-1H-pyrazole-3-carboxylate 
• 637022-63-0 4-chloro-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 1124157-43-2 4-chloro-5-methyl-1H-pyrazole-3-carboxylic acid dibutylamide 
• 1445778-96-0 4-chloro-1-(2-cyano-4-methoxyphenyl)-5-methyl-1H-pyrazole-3-carboxylic acid dibutylamide 
• 1445778-97-1 2-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-5-methoxybenzoic acid 
• 1445778-81-3 4-chloro-1-[2-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)-4-methoxyphenyl]-5-methyl-1H-pyrazole-3-carboxylic acid dibutylamide 
• 1445778-80-2 4-chloro-1-[4-hydroxy-2-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)-phenyl]-5-methyl-1H-pyrazole-3-carboxylic acid dibutylamide 
• 623-48-3 ethyl iodoacetae 

Downstream Products

• 1445778-73-3 [4-(4-chloro-3-dibutylcarbamoyl-5-methylpyrazol-1-yl)-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)phenoxy]acetic acid 
• 1445778-74-4 4-chloro-1-[2-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)-4-phenylcarbamoylmethoxyphenyl]-5-methyl-1H-pyrazole-3-carboxylic acid dibutylamide 

Relevant academic research and scientific papers

COMPOUNDS FOR INHIBITING THE INTERACTION OF BCL2 WITH BINDING PARTNERS

The present invention relates to compounds of formula I: in which R1, R2, R3 and R4 are as defined in the Summary of the Invention. Compounds of formula I are capable of disrupting the BCL-2 interations with proteins containing a BH3 domain. Disrupting this interaction can restore the anti-apoptotic function of BCL-2 in cancer cells and tumor tissue expressing BCL-2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancerous diseases.