1445804-99-8

Basic information

• Product Name: C₁₅H₁₆ClNO₂S
• Synonyms: C₁₅H₁₆ClNO₂S
• CAS NO: 1445804-99-8
• Molecular Weight: 309.817
• Mol File: 1445804-99-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₆ClNO₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₆ClNO₂S(1445804-99-8)
• EPA Substance Registry System: C₁₅H₁₆ClNO₂S(1445804-99-8)

Safety Data

• Hazardous Substances Data: 1445804-99-8(Hazardous Substances Data)

Upstream product

• 7569-87-1 3-chloro-4-methoxyphenethylamine 
• 23060-85-7 3-hydroxy-2-methylpyran-4(1H)-thione 

Relevant articles and documents

Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors

Streptococcus pneumoniae relies on a number of virulence factors, including immunoglobulin A1 protease (IgA1P), a Zn2+ metalloprotease produced on the extracellular surface of the bacteria, to promote pathogenic colonization. IgA1P exhibits a unique function, in that it catalyzes the proteolysis of human IgA1 at its hinge region to leave the bacterial cell surface masked by IgA1 Fab, enabling the bacteria to evade the host's immune system and adhere to host epithelial cells to promote colonization. Thus, S. pneumoniae IgA1P has emerged as a promising antibacterial target; however, the lack of an appropriate screening assay has limited the investigation of this metalloprotease virulence factor. Relying on electrostatics-mediated AuNP aggregation, we have designed a promising high-throughput colorimetric assay for IgA1P. By using this assay, we have uncovered inhibitors of the enzyme that should be useful in deciphering its role in pneumococcal colonization and virulence.