1445858-85-4

Basic information

• Product Name: C₁₄H₁₄O₃
• CAS NO: 1445858-85-4
• Molecular Weight: 230.263
• Mol File: 1445858-85-4.mol

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₄O₃(1445858-85-4)
• EPA Substance Registry System: C₁₄H₁₄O₃(1445858-85-4)

Safety Data

• Hazardous Substances Data: 1445858-85-4(Hazardous Substances Data)

Upstream product

• 169779-84-4 (2RS)-methyl-3-oxopentanoyl-N-acetylcysteamine thioester 
• 64074-05-1 2,2-dimethyl-5-propanoyl-1,3-dioxan-4,6-dione 

Relevant articles and documents

Promiscuity of a modular polyketide synthase towards natural and non-natural extender units

Combinatorial biosynthesis approaches that involve modular type I polyketide synthases (PKSs) are proven strategies for the synthesis of polyketides. In general however, such strategies are usually limited in scope and utility due to the restricted substrate specificity of polyketide biosynthetic machinery. Herein, a panel of chemo-enzymatically synthesized acyl-CoA's was used to probe the promiscuity of a polyketide synthase. Promiscuity determinants were dissected, revealing that the KS is remarkably tolerant to a diverse array of extender units, while the AT likely discriminates between extender units that are native to the producing organism. Our data provides a clear blueprint for future enzyme engineering efforts, and sets the stage for harnessing extender unit promiscuity by employing various in vivo polyketide diversification strategies. The Royal Society of Chemistry 2013.