1445904-49-3

Basic information

• Product Name: 1,3-bis(5-N′-hydroxyamidinopyridin-3-yl)benzene
• CAS NO: 1445904-49-3
• Molecular Weight: 348.364
• Mol File: 1445904-49-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-bis(5-N′-hydroxyamidinopyridin-3-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(5-N′-hydroxyamidinopyridin-3-yl)benzene(1445904-49-3)
• EPA Substance Registry System: 1,3-bis(5-N′-hydroxyamidinopyridin-3-yl)benzene(1445904-49-3)

Safety Data

• Hazardous Substances Data: 1445904-49-3(Hazardous Substances Data)

Upstream product

• 1445904-47-1 1,3-bis(5-cyanopyridin-3-yl)benzene 
• 402718-29-0 3-cyanopyridine-5-boronic acid pinacol ester 
• 35590-37-5 5-bromopyridine-3-carbonitrile 

Relevant articles and documents

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives

4,4″-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Plasmodium falciparum, and Leishmania amazonensis. Twenty-three compounds were highly active against T. b. rhodesiense or P. falciparum. Most noteworthy were amidines 1, 10, and 11 with IC50 of 4 nM against T. b. rhodesiense, and dimethyltetrahydropyrimidinyl analogues 4 and 9 with IC50 values of ≤ 3 nM against P. falciparum. Bis-pyridylimidamide derivative 31 was 25 times more potent than benznidazole against T. cruzi and slightly more potent than amphotericin B against L. amazonensis. Terphenyldiamidine 1 and dipyridylbenzene analogues 23 and 25 each cured 4/4 mice infected with T. b. rhodesiense STIB900 with four daily 5 mg/kg intraperitoneal doses, as well as with single doses of ≤10 mg/kg. Derivatives 5 and 28 (prodrugs of 1 and 25) each cured 3/4 mice with four daily 25 mg/kg oral doses.