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1445905-51-0

N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-guanosine-2'-cyanoethylPhosphoramidite, also known as 3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine 2'-CE phosphoramidite, is a DMT protected nucleoside with potential anticancer properties. It plays a crucial role in the synthesis of DNA and RNA and can be utilized as an activator for enzymatic reactions.

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  • N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-guanosine-2'-cyanoethylPhosphoramidite

    Cas No: 1445905-51-0

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  • NewCan Biotech Limited
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  • (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

    Cas No: 1445905-51-0

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  • Win-Win chemical Co.Ltd
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  • 1445905-51-0 Structure

  • Basic information

    1. Product Name: 3'-TBDMS-ibu-rG Phosphoramidite
    2. Synonyms: 3'-TBDMS-ibu-rG Phosphoramidite;3'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine 2'-CE phosphoramidite
    3. CAS NO:1445905-51-0
    4. Molecular Formula: C50H68N7O9PSi
    5. Molecular Weight: 970.18
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 1445905-51-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 8.68±0.20(Predicted)
    10. CAS DataBase Reference: 3'-TBDMS-ibu-rG Phosphoramidite(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3'-TBDMS-ibu-rG Phosphoramidite(1445905-51-0)
    12. EPA Substance Registry System: 3'-TBDMS-ibu-rG Phosphoramidite(1445905-51-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1445905-51-0(Hazardous Substances Data)

1445905-51-0 Usage

Uses

Used in Pharmaceutical Industry:
N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-guanosine-2'-cyanoethylPhosphoramidite is used as a key component in the preparation of cyclic dinucleotides, which serve as STING-activating messengers. These messengers are essential for enhancing the immune response against various diseases, including cancer.
Used in DNA and RNA Synthesis:
N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-guanosine-2'-cyanoethylPhosphoramidite is used as a nucleotide in the synthesis of DNA and RNA, which are the fundamental building blocks of genetic material in living organisms. Its role in the synthesis process is vital for the accurate replication and transcription of genetic information.
Used in Anticancer Applications:
N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-guanosine-2'-cyanoethylPhosphoramidite has demonstrated potential anticancer properties, making it a promising candidate for further research and development in the field of cancer therapeutics. Its ability to activate enzymatic reactions may contribute to the development of novel cancer treatment strategies.

Check Digit Verification of cas no

The CAS Registry Mumber 1445905-51-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,5,9,0 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1445905-51:
(9*1)+(8*4)+(7*4)+(6*5)+(5*9)+(4*0)+(3*5)+(2*5)+(1*1)=170
170 % 10 = 0
So 1445905-51-0 is a valid CAS Registry Number.

1445905-51-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1445905-51-0 SDS

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