1446-17-9

Basic information

• Product Name: Chloroquinine phosphate
• Synonyms: Chloroquinine phosphate
• CAS NO: 1446-17-9
• Molecular Formula: C18H26ClN3•H3O4P
• Molecular Weight: 417.92
• Mol File: 1446-17-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 460.6°Cat760mmHg
• Flash Point: 232.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.15E-08mmHg at 25°C
• CAS DataBase Reference: Chloroquinine phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: Chloroquinine phosphate(1446-17-9)
• EPA Substance Registry System: Chloroquinine phosphate(1446-17-9)

Safety Data

• Hazardous Substances Data: 1446-17-9(Hazardous Substances Data)

Usage

Safety Profile

Human poison by ingestion.Human systemic effects by ingestion: muscle weakness. Ahuman teratogen. Human reproductive effects:termination of pregnancy; developmental abnormalities ofthe eye, ear, and musculoskeletal system; and effects onnewborn and p

InChI:InChI=1/C18H26ClN3.H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);(H3,1,2,3,4)

Upstream product

• 54-05-7 Chloroquine 

Relevant articles and documents

Preparation method of chloroquine phosphate

The invention discloses a preparation method of chloroquine phosphate, namely 7-chloro-4-(4-diethylamino-1-methylbutylamino)quinoline diphosphate. The preparation method comprises the following steps: (1) carrying out a condensation reaction on 4,7-dichloroquinoline and 2-amino-5-diethylaminopentane, and carrying out alkalization extraction, concentration and crystallization to obtain chloroquine; and (2) salifying the chloroquine obtained in the step (1) and phosphoric acid to obtain chloroquine phosphate. The method avoids the use of phenol, is simple in reaction, and is beneficial to industrial production; and the chloroquine is crystallized to improve the purity and then salified with the phosphoric acid, so product appearance is good, the purity of the produced chloroquine phosphate is greater than or equal to 99.5%, and a single impurity is less than 0.1% (according to an HPLC area normalization method).