1446029-75-9Relevant academic research and scientific papers
New cytotoxic 1,2,4-thiadiazole alkaloids from the ascidian Polycarpa aurata
Pham, Cong-Dat,Weber, Horst,Hartmann, Rudolf,Wray, Victor,Lin, Wenhan,Lai, Daowan,Proksch, Peter
, p. 2230 - 2233 (2013)
Two new alkaloids, polycarpathiamines A and B (1 and 2), were isolated from the ascidian Polycarpa aurata. Their structures were unambiguously determined by 1D, 2D NMR, and HRESIMS measurements and further confirmed by comparison with a closely related analogue, 3-dimethylamino-5-benzoyl-1,2,4-thiadiazole (4), that was prepared by chemical synthesis. Compounds 1 and 2 both feature an uncommon 1,2,4-thiadiazole ring whose biosynthetic origin is proposed. Compound 1 showed significant cytotoxic activity against L5178Y murine lymphoma cells (IC50 0.41 μM).
