1446095-07-3

Basic information

• Product Name: (2R,3R,4R,5R,6R)-tert-butyl 6-((1,3-dioxolan-2-yl)methyl)-4-(4-bromophenyl)-2,3-dihydroxy-5-phenyltetrahydro-2H-pyran-2-carboxylate
• Synonyms: (2R,3R,4R,5R,6R)-tert-butyl 6-((1,3-dioxolan-2-yl)methyl)-4-(4-bromophenyl)-2,3-dihydroxy-5-phenyltetrahydro-2H-pyran-2-carboxylate
• CAS NO: 1446095-07-3
• Molecular Weight: 535.432
• Mol File: 1446095-07-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3R,4R,5R,6R)-tert-butyl 6-((1,3-dioxolan-2-yl)methyl)-4-(4-bromophenyl)-2,3-dihydroxy-5-phenyltetrahydro-2H-pyran-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,4R,5R,6R)-tert-butyl 6-((1,3-dioxolan-2-yl)methyl)-4-(4-bromophenyl)-2,3-dihydroxy-5-phenyltetrahydro-2H-pyran-2-carboxylate(1446095-07-3)
• EPA Substance Registry System: (2R,3R,4R,5R,6R)-tert-butyl 6-((1,3-dioxolan-2-yl)methyl)-4-(4-bromophenyl)-2,3-dihydroxy-5-phenyltetrahydro-2H-pyran-2-carboxylate(1446095-07-3)

Safety Data

• Hazardous Substances Data: 1446095-07-3(Hazardous Substances Data)

Upstream product

• 19693-75-5 2-methoxy-1,3-dioxolane 
• 1446094-78-5 (2R,3R,4S)-tert-butyl 4-(4-bromophenyl)-2-(2-oxoethyl)-3-phenyl-3,4-dihydro-2H-pyran-6-carboxylate 
• 1379601-12-3 (E)-tert-butyl 4-(4-bromophenyl)-2-oxobut-3-enoate 

Relevant articles and documents

Dienamine-mediated inverse-electron-demand hetero-diels-alder reaction by using an enantioselective H-bond-directing strategy

The first H-bond-directed inverse-electrondemand hetero-Diels-Alder reaction proceeding via a dienamine intermediate was developed. Under optimized reaction conditions, the corresponding dienamine species underwent regio- and stereoselective functionalization at the remote double bond, five bonds away from the stereogenic center of the catalyst, to give dihydropyran derivatives bearing three contiguous stereogenic centers. High stereoselectivities were obtained by employing a bifunctional squaramide-containing aminocatalyst, and the rationalization for the stereochemical outcome of the reaction was provided. Furthermore, the possibility to employ the introduced chiral framework for the synthesis of tetrahydropyrans as well as polycyclic compounds was demonstrated.