144610-82-2Relevant academic research and scientific papers
Studies directed toward the total synthesis of 14-membered cyclopeptide alkaloids: Synthesis of a cyclic precursor to nummularine-F
Heffner,Joullie
, p. 7021 - 7024 (1989)
A highly strained 14-membered para-ansa cyclopeptide, a potential precursor of the cyclopeptide alkaloid, nummularine-F, was made by cyclization of a pentafluorophenyl ester under catalytic hydrogenation conditions. This cyclization and the stereoselective synthesis of the acyclic activated ester from D-serine, are presented.
Total synthesis of (-)-nummularine F
Heffner, Robert J.,Jiang, Jianjun,Joullié, Madeleine M.
, p. 10181 - 10189 (2007/10/02)
The first total synthesis of the 14-membered para ansa cyclopeptide alkaloid (-)-nummularine F is reported. The pivotal transformations of the synthetic strategy are (1) a stereocontrolled approach for introducing the absolute stereochemistry at the α- an
