1446139-96-3Relevant articles and documents
Development of asymmetric deacylative allylation
Grenning, Alexander J.,Van Allen, Christie K.,Maji, Tapan,Lang, Simon B.,Tunge, Jon A.
, p. 7281 - 7287 (2013)
Herein we present the development of asymmetric deacylative allylation of ketone enolates. The reaction directly couples readily available ketone pronucleophiles with allylic alcohols using facile retro-Claisen cleavage to form reactive intermediates in situ. The simplicity and robustness of the reaction conditions is demonstrated by the preparation of >6 g of an allylated tetralone from commercially available materials. Furthermore, use of nonracemic PHOX ligands allows intermolecular formation of quaternary stereocenters directly from allylic alcohols.
