144617-65-2Relevant academic research and scientific papers
Cascade reaction of propargylic alcohols with hydroxylamine hydrochloride: facile synthesis of α,β-unsaturated oximes and nitriles
Zhang, Qi,Zhang, Linjing,Tang, Chaojun,Luo, Huan,Cai, Xuediao,Chai, Yonghai
, p. 6935 - 6942 (2016/10/14)
We have developed an easy and practical method for the synthesis of α,β-unsaturated oximes and nitriles from readily available propargylic alcohols with hydroxylamine hydrochloride (NH2OH·HCl) under metal-free conditions. By using or not using p-toluenesulfonyl chloride (p-TsCl) as the dehydrating promoter, the desired nitriles or oximes could be obtained, respectively via a three-step one-pot or two-step one-pot process in moderate to excellent yields with good functional group compatibility.
Silver-Catalyzed Long-Distance Aryl Migration from Carbon Center to Nitrogen Center
Zhou, Taigang,Luo, Fei-Xian,Yang, Ming-Yu,Shi, Zhang-Jie
supporting information, p. 14586 - 14589 (2015/12/08)
Selective cleavage of an inert C-C bond followed by C-O/N bond formation through a long-distance aryl migration from a carbon to a nitrogen center via Ag catalysis is reported. The migration products were easily converted into γ-hydroxy amines and tetrahy
Electrocyclic Aromatic Substitution by Nitrile Ylides to give 3H-2-Benzazepines: Substituent Effects and Mechanism
Groundwater, Paul W.,Sharp, John T.
, p. 7951 - 7964 (2007/10/02)
Benzonitrile 3,3-diarylallyl nitrile ylides (16), generated by the base-induced dehydrochlorination of imidoyl chlorides, cyclised by 1,7-ring closure to give 3H-2-benzazepines e.g. (19), in contrast to analogous diazo-compounds (1) which prefer 1,5-elect
