1446183-03-4

Basic information

• Product Name: 5-amino-2-(oxazol-2-yl)-4-phenylthiazole
• Synonyms: 5-amino-2-(oxazol-2-yl)-4-phenylthiazole
• CAS NO: 1446183-03-4
• Molecular Weight: 243.289
• Mol File: 1446183-03-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-amino-2-(oxazol-2-yl)-4-phenylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-2-(oxazol-2-yl)-4-phenylthiazole(1446183-03-4)
• EPA Substance Registry System: 5-amino-2-(oxazol-2-yl)-4-phenylthiazole(1446183-03-4)

Safety Data

• Hazardous Substances Data: 1446183-03-4(Hazardous Substances Data)

Upstream product

• 1353513-69-5 2-thioformyloxazole 
• 53641-60-4 2-phenylglycinonitrile hydrochloride 
• 65373-52-6 oxazole-2-carbaldehyde 
• 40943-70-2 a-aminophenylacetonitrile hydrochloride 

Downstream Products

• 1446183-04-5 (S)-tert-butyl 2-(2-(oxazol-2-yl)-4-phenylthiazol-5-ylcarbamoyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

9H-PYRIMIDO[4,5-B]INDOLES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS

The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

INHIBITORS OF IAP

Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1,R2,R3,R4,R5 and R6 are as described herein.