1446211-19-3Relevant academic research and scientific papers
Copper-catalyzed enantioselective intramolecular N -arylation, an efficient method for kinetic resolutions
Yang, Wenqiang,Long, Yan,Zhang, Shasha,Zeng, Youlin,Cai, Qian
, p. 3598 - 3601 (2013)
For the first time, copper-catalyzed intramolecular N-arylation was successfully applied to the kinetic resolution strategy. Under the catalysis of CuI-BINOL derived ligands, the kinetic resolution of rac-2-amino-3-(2-iodoaryl) propionates and rac-2-amino-4-(2-iodoaryl)butanoates afforded chiral intramolecular coupling products and recovered the starting materials in high enantioselectivity (s factors up to 245).
