1446261-69-3

Basic information

• Product Name: (R)-benzyl 2-ethynyl-2-methylpyrrolidine-1-carboxylate
• Synonyms: (R)-benzyl 2-ethynyl-2-methylpyrrolidine-1-carboxylate
• CAS NO: 1446261-69-3
• Molecular Weight: 243.305
• Mol File: 1446261-69-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-benzyl 2-ethynyl-2-methylpyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-benzyl 2-ethynyl-2-methylpyrrolidine-1-carboxylate(1446261-69-3)
• EPA Substance Registry System: (R)-benzyl 2-ethynyl-2-methylpyrrolidine-1-carboxylate(1446261-69-3)

Safety Data

• Hazardous Substances Data: 1446261-69-3(Hazardous Substances Data)

Usage

General Description

(R)-benzyl 2-ethynyl-2-methylpyrrolidine-1-carboxylate is a chemical compound with the molecular formula C14H15NO2. It is a derivative of pyrrolidine and contains both an ethynyl and a benzyl functional group. (R)-benzyl 2-ethynyl-2-methylpyrrolidine-1-carboxylate has potential applications in organic synthesis and pharmaceutical research. Its unique structure and reactivity make it useful as a building block for the synthesis of complex organic molecules. Additionally, it may have potential pharmacological properties due to its structural resemblance to certain bioactive compounds. Its precise uses and properties may require further investigation and study.

Upstream product

• 220060-08-2 (R)-2-methylpyrrolidine-2-carboxylic acid methyl ester hydrochloride 
• 1330286-50-4 (3S,7aR)-3-(trichloromethyl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-1-one 
• 19734-16-8 diethyl (1-diazo-2-oxo-2-phenylethyl)phosphonate 
• 344-25-2 D-Prolin 

Downstream Products

• 1446261-61-5 (R)-methyl 9-fluoro-11b-methyl-6-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-7-carboxylate 
• 1446261-44-4 (10aR)-2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one 
• 1446261-52-4 (R)-benzyl 2-((2-amino-6-(methoxycarbonyl)phenyl)ethynyl)-2-methylpyrrolidine-1-carboxylate 
• 1446261-57-9 (R)-benzyl 2-((4-fluoro-2-(methoxycarbonyl)-6-(2,2,2-trifluoroacetamido)phenyl)ethynyl)-2-methylpyrrolidine-1-carboxylate 
• 1446261-55-7 (R)-methyl 11b-methyl-6-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-7-carboxylate 
• 1446261-51-3 (R)-methyl 2-(1-(benzyloxycarbonyl)-2-methyltetrahydropyrrol-2-yl)-1H-indole-4-carboxylate 

Relevant articles and documents

Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development

Poly (ADP-ribose) polymerase (PARP) plays a significant role in DNA repair responses; therefore, this enzyme is targeted by PARP inhibitors in cancer therapy. Here we have developed a number of fused tetra- or pentacyclic dihydrodiazepinoindolone derivatives with excellent PARP enzymatic and cellular PARylation inhibition activities. These efforts led to the identification of pamiparib (BGB-290, 139), which displays excellent PARP-1 and PARP-2 inhibition with IC50 of 1.3 and 0.9 nM, respectively. In a cellular PARylation assay, this compound inhibits PARP activity with IC50 = 0.2 nM. Cocrystal of pamiparib shows similar binding sites with PARP with other PARP inhibitors, but pamiparib is not a P-gp substrate and shows excellent drug metabolism and pharmacokinetics (DMPK) properties with significant brain penetration (17-19%, mice). The compound is currently being investigated in phase III clinical trials as a maintenance therapy in platinum-sensitive ovarian cancer and gastric cancer.