Linagliptin iMpurity E, also known as Des-(R)-piperidin-3-amine 8-(R)-(Piperidin-3-ylamino) Linagliptin, is an impurity of Linagliptin (L465900). Linagliptin is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, which is a type of medication used for the treatment of type 2 diabetes. The presence of Linagliptin iMpurity E may affect the efficacy and safety of Linagliptin, making it an important consideration in the manufacturing and quality control processes.
1446263-38-2
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Basic information
- Product Name: Linagliptin iMpurity E
- Synonyms: (R)-7-(but-2-ynyl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-8-(piperidin-3-ylaMino)-1H-purine-2,6(3H,7H)-dione;Linagliptin iMpurity E;Linagliptin Impurity 27
- CAS NO:1446263-38-2
- Molecular Formula: C25H28N8O2
- Molecular Weight: 472.54222
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1446263-38-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Linagliptin iMpurity E(CAS DataBase Reference)
- NIST Chemistry Reference: Linagliptin iMpurity E(1446263-38-2)
- EPA Substance Registry System: Linagliptin iMpurity E(1446263-38-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1446263-38-2(Hazardous Substances Data)
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1446263-38-2 Usage
Uses
Used in Pharmaceutical Industry:Linagliptin iMpurity E is used as a reference compound for the development and validation of analytical methods in the pharmaceutical industry. It helps in the identification, quantification, and control of impurities in Linagliptin, ensuring the quality and safety of the final drug product.
Linagliptin iMpurity E is also used as a research tool for studying the effects of impurities on the pharmacokinetics, pharmacodynamics, and safety profile of Linagliptin. This information is crucial for optimizing the drug's formulation and dosing regimen, as well as for evaluating its potential for drug-drug interactions.
Additionally, Linagliptin iMpurity E can be used in the development of new drug candidates with improved selectivity and potency against DPP-4. By understanding the structure-activity relationship of Linagliptin and its impurities, researchers can design more effective and safer medications for the treatment of type 2 diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 1446263-38-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,6,2,6 and 3 respectively; the second part has 2 digits, 3 and 8 respectively.Calculate Digit Verification of CAS Registry Number 1446263-38:
(9*1)+(8*4)+(7*4)+(6*6)+(5*2)+(4*6)+(3*3)+(2*3)+(1*8)=162
162 % 10 = 2
So 1446263-38-2 is a valid CAS Registry Number.
1446263-38-2Upstream product
1446263-38-2Downstream Products
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Linagliptin iMpurity E
