1446271-24-4Relevant academic research and scientific papers
Enantioselective Mukaiyama-Michael with 2-enoyl pyridine N-oxides catalyzed by PYBOX-DIPH-Zn(ii)-complexes at ambient temperature
Rout, Subhrajit,Ray, Sumit K.,Singh, Vinod K.
, p. 4537 - 4545 (2013/08/23)
A chiral PYBOX-DIPH-Zn(ii) catalyzed enantioselective Mukaiyama-Michael reaction of acyclic silyl enol ethers with 2-enoylpyridine N-oxides has been studied in external additive free conditions at ambient temperature. The methodology offers straightforward access to a variety of functionalized chiral 1,5-dicarbonyl compounds, which could easily be elaborated into synthetically viable pyrones via hydrolysis followed by cyclization. A transition state model has been proposed to explain the stereochemical outcome. The Royal Society of Chemistry 2013.
