144632-49-5Relevant academic research and scientific papers
A chiral primary amine thiourea catalyst for the highly enantioselective direct conjugate addition of α,α-disubstituted aldehydes to nitroalkenes
Lalonde, Mathieu P.,Chen, Yonggang,Jacobsen, Eric N.
, p. 6366 - 6370 (2007/10/03)
(Chemical Equation Presented) Dual activation: The bifunctional primary amine thiourea catalyst 1 promotes the highly enantioselective direct conjugate addition of α-branched aldehydes to nitroalkenes (see scheme). Cooperative activation of both the nucleophile and electrophile allows the use of mild reaction conditions and provides access to a wide variety of adducts with vicinal quaternary and tertiary stereogenic centers (>90% ee).
N-(2-Phenylprop-1-enyl)proline Methyl Ester: Equilibrium between the Enamine and the Aza Methine Ylide Form
Felluga, Fulvia,Nitti, Patrizia,Pitacco, Giuliana,Valentin, Ennio
, p. 2331 - 2336 (2007/10/02)
The title compound reacted with nitroolefins to give either cyclobutanes or pyrrolizidine derivatives, depending on whether it acted as an enamine or as a 1,3-dipole.
