1446321-17-0Relevant academic research and scientific papers
Efficient bakers yeast-catalyzed multicomponent synthesis of α-aminophosphonates in one pot
Bhattacharya, Asish K.,Mujahid, Mohammad
, p. 2583 - 2589 (2013)
Utilizing bakers yeast (Saccharomyces cerevisiae) as a biocatalyst, synthesis of α-aminophosphonates in one pot has been accomplished by the three-component reaction of an aldehyde, an amine, and diethyl phosphite in moderate to good yields under solvent-
Diversity-oriented synthesis of α-aminophosphonates: A new class of potential anticancer agents
Bhattacharya, Asish K.,Raut, Dnyaneshwar S.,Rana, Kalpeshkumar C.,Polanki, Innaiah K.,Khan, Mohd Sajid,Iram, Sana
supporting information, p. 146 - 152 (2013/10/01)
A small library of structurally diverse α-aminophosphonates has been synthesized by reacting alkyl/aryl aldehydes, alkyl/aryl amines and alkyl/aryl phosphites in one-pot catalyzed by Amberlite-IR 120 resin (acidic). All the synthesized a-aminophosphonates were assayed for their in vitro cytotoxic activities against a panel of five human cancer cell lines including A-549, NCI-H23 (Lung), Colo 320DM (Colon), MG-63 (Bone marrow) and Jurkat (Blood T lymphocytes). Compound 4n having (R)-1-phenylethanamine was found to be the most active amongst all the synthesized a-aminophosphonates against all the five cancer cell lines, most prominent being against Jurkat cell line with an IC 50 value of 4 μM. Surprisingly, compound 4o having (S)-1-phenylethanamine was found to be devoid of any cytotoxicity. Our finding suggests that these chemical entities could further serve as interesting template for the design of potential anticancer agents.
