1446322-32-2Relevant academic research and scientific papers
Chemistry of ring-substituted 4-(benzothiazol-2-yl)phenylnitrenium ions from antitumor 2-(4-aminophenyl)benzothiazoles
Zhang, Yang,Chakraborty, Mrinal,Cerda-Smith, Christian G.,Bratton, Ryan N.,Maurer, Natalie E.,Senser, Ethan M.,Novak, Michael
, p. 6992 - 7000 (2013/08/23)
Ring-substituted derivatives of 2-(4-aminophenyl)benzothiazole, 1a, 1b-g, are under development as antitumor agents. One derivative, 1f, has reached phase 1 clinical trials as the prodrug 2f, Phortress (NSC 710305). These amines are activated by CYP450 1A
