1446326-19-7

Basic information

• Product Name: C₃₀H₂₉FN₃O₄P
• Synonyms: C₃₀H₂₉FN₃O₄P
• CAS NO: 1446326-19-7
• Molecular Weight: 545.55
• Mol File: 1446326-19-7.mol

Chemical Properties

• CAS DataBase Reference: C₃₀H₂₉FN₃O₄P(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₂₉FN₃O₄P(1446326-19-7)
• EPA Substance Registry System: C₃₀H₂₉FN₃O₄P(1446326-19-7)

Safety Data

• Hazardous Substances Data: 1446326-19-7(Hazardous Substances Data)

Upstream product

• 1446326-18-6 ciprofloxacin 
• 96776-80-6 diphenyl-bis(hydroxymethyl)phosphonium chloride 
• 5958-44-1 diphenylphosphinomethanol 

Relevant articles and documents

Synthesis, properties and biological activity of a novel phosphines ligand derived from ciprofloxacin

Novel potential antibacterial agents derived from ciprofloxacin (HCp) were synthesized in the reaction of this antibiotic with hydroxymethyldiphenylphosphine. Detailed analysis by the NMR, IR and MS techniques attested to the identity and structure of the obtained compounds. In addition, the structure of phosphine PPh2CH2-Cp was unambiguously confirmed by X-ray crystal structural analysis. PPh 2CH2-Cp exhibited an antibacterial activity comparable to that of the original drug. Cytotoxicity studies revealed that this compound was characterized by lower toxicity against mammalian cells than HCp. Besides, it did not induce a morphological change in cells after its action and was unable to degrade plasmid DNA, as well as parent antibiotic. Our results open up new possibilities in designing novel, less toxic and comparably effective antibiotics drugs.