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1446332-69-9

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1446332-69-9 Usage

General Description

Tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate is a chemical compound with the molecular formula C19H25N3O4. It is a piperazine derivative with a tert-butyl ester group attached to the piperazine ring. The compound also contains a formyl group and a hydroxyphenyl group, which are attached to the piperazine nitrogen atoms. This chemical compound is used in the synthesis of pharmaceuticals and other organic compounds due to its unique structure and potential biological activity. It may have applications in the development of drug molecules with therapeutic properties.

Check Digit Verification of cas no

The CAS Registry Mumber 1446332-69-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,6,3,3 and 2 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1446332-69:
(9*1)+(8*4)+(7*4)+(6*6)+(5*3)+(4*3)+(3*2)+(2*6)+(1*9)=159
159 % 10 = 9
So 1446332-69-9 is a valid CAS Registry Number.

1446332-69-9Relevant articles and documents

Dual-biomarker-triggered fluorescence probes for differentiating cancer cells and revealing synergistic antioxidant effects under oxidative stress

Zhang, Changyu,Zhang, Qiang-Zhe,Zhang, Kun,Li, Lu-Yuan,Pluth, Michael D.,Yi, Long,Xi, Zhen

, p. 1945 - 1952 (2019)

Hydrogen sulfide (H2S) and human NAD(P)H:quinine oxidoreductase 1 (hNQO1) are potential cancer biomarkers and also vital participants in cellular redox homeostasis. Simultaneous detection of these two biomarkers would benefit the diagnostic precision of related cancers and could also help to investigate their crosstalk in response to oxidative stress. Despite this importance, fluorescent probes that can be activated by the dual action of H2S detection and hNQO1 activity have not been investigated. To this end, dual-biomarker-triggered fluorescent probes 1 and 2 were rationally constructed by installing two chemoselective triggering groups into one fluorophore. Probe 1 provides a small turn-on fluorescence response toward H2S but a much larger response to both H2S and hNQO1 in tandem. By contrast, fluorescence probe 2 is activated only in the presence of both H2S and hNQO1. Probe 2 exhibits a large fluorescence turn-on (>400 fold), high sensitivity, excellent selectivity as well as good biocompatibility, enabling the detection of both endogenous H2S and hNQO1 activity in living cells. Bioimaging results indicated that probe 2 could differentiate HT29 and HepG2 cancer cells from HCT116, FHC and HeLa cells owing to the existence of relatively high endogenous levels of both biomarkers. Expanded investigations using 2 revealed that cells could generate more endogenous H2S and hNQO1 upon exposure to exogenous hydrogen peroxide (H2O2), implying the synergistic antioxidant effects under conditions of cellular oxidative stress.

Compounds for treating spinal muscular atrophy

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Page/Page column 319; 320, (2017/05/02)

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

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Paragraph 00578; 00579, (2013/07/19)

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

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