1446357-61-4

Upstream product

• 870244-34-1 3,5-dibromopyridine-4-carbonitrile 
• 1446393-80-1 sodium benzoyl(3,5-dibromoisonicotinoyl)amide 
• 618-39-3 benzamidin 

Downstream Products

• 1446393-82-3 sodium (3,5-dibromoisonicotinoyl)(4-methoxybenzoyl)amide 
• 1446393-81-2 sodium (3,5-dibromoisonicotinoyl)(3-methoxybenzoyl)amide 
• 1446393-80-1 sodium benzoyl(3,5-dibromoisonicotinoyl)amide 
• 1446357-45-4 5-bromo-2-phenyl-4H-pyrido[4,3-e][1,3]oxazin-4-one 
• 1446357-46-5 5-bromo-2-(3-methoxyphenyl)-4H-pyrido[4,3-e][1,3]oxazin-4-one 
• 1446357-47-6 5-bromo-2-(4-methoxyphenyl)-4H-pyrido[4,3-e][1,3]oxazin-4-one 
• 1616763-11-1 5-bromo-2-(4-chlorophenyl)-4H-pyrido[4,3-e][1,3]oxazin-4-one 
• 1616763-36-0 5-bromo-4-(4-(4-chlorophenyl)-6-phenyl-1,3,5-triazin-2-yl)pyridin-3-ol 
• 1616763-39-3 4-(4-amino-6-(4-chlorophenyl)-1,3,5-triazin-2-yl)-5-bromopyridin-3-ol 
• 1616763-14-4 sodium (3,5-dibromoisonicotinoyl)(4-chlorobenzoyl)amide 

Relevant academic research and scientific papers

Access to pyridyl-substituted 1,3,5-triazines from 4 H-pyrido[1,3]oxazin-4- ones via a cyclocondensation process

Pyridyl-substituted 1,3,5-triazines were synthesized in good to excellent yields via an unprecedented one-step cyclocondensation of 4H-pyrido[1,3]oxazin- 4-ones with amidines at room temperature or under microwave irradiations. The broad applicability was demonstrated by 33 examples with a variety of amidines and three different 4H-pyrido[1,3]oxazin-4-one chemical series. In addition, a one-pot process from 4H-pyrido[1,3]oxazin-4-one precursors (imide sodium salts) was developed and led to the desired triazines compounds, thus allowing a one-step economy in their global synthetic preparation. This approach provides rapid access to pyridyl (or pyridone)-substituted 1,3,5-triazines with high potential in various fields of application.

Expeditive access to 2-substituted 4 h -pyrido[1,3]oxazin-4-ones via an intramolecular O-arylation

Unreported 2-substituted 4H-pyrido[e][1,3]oxazin-4-ones are synthesized via an unprecedented intramolecular O-arylation of N-aroyl- and N-heteroaroyl-(iso)nicotinamides under microwave irradiations, in good to excellent yields. The broad applicability was demonstrated by 24 examples with a variety of substituents at the 2-position of the final compounds and 3 possible positions for the nitrogen atom of the pyridine ring. In addition, transformation of one of these compounds into 2-hydroxypyridyl-substituted 1,2,4-triazole and 1,2,4-oxazinone was realized. This approach opens a rapid access to a new bicyclic heteroaromatic chemical series with high potential in medicinal chemistry.