144640-75-5

Usage

Chemical Properties

Pale Yellow Solid

Upstream product

• 961-07-9 2'-Deoxyguanosine 
• 961-07-9 2'-deoxyguanosine 
• 69992-10-5 3’,5’-O-diacetyl-2’-deoxyguanosine 
• 100-51-6 benzyl alcohol 
• 69992-10-5 3',5'-di-O-acetyl-2'-deoxyguanosine 

Downstream Products

• 129732-90-7 O⁶-Benzyl-2'-deoxyguanosine 
• 849830-81-5 2-chloro-6-benzyloxy-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate 
• 849830-86-0 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{6-benzyloxy-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-naphthalen-1-ylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester 
• 144640-76-6 O⁶-benzyl-2-fluoro-2'-deoxyinosine 

Relevant academic research and scientific papers

BETA-GLUGURONIDASE CLEAVABLE PRODRUGS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE INACTIVATORS

Disclosed are prodrugs of inactivators of 06-alkylguanine-DNA alkyltransferase (AGT). The prodrugs are cleavable by the (3-glucuronidase enzyme, which is either administered to the patient or produced by necrotic tumor cells. The prodrugs are r

β-Glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2′-deoxyguanosine

Glucuronic acid linked prodrugs of O6-benzylguanine and O 6-benzyl-2′-deoxyguanosine were synthesized. The prodrugs were found to be quite stable at physiological pH and were more than 200-fold less active as inactivators of O6

Epoxide and diol epoxide adducts of polycyclic aromatic hydrocarbons at the exocyclic amino group of deoxyguanosine

Synthesis and separation of the diastereomeric trans N2-2'-deoxyguanosine adducts of tetrahydrophenanthrene 3,4-epoxide and benzo[a]pyrene 7,8-diol 9,10-epoxide (benzylic hydroxyl group and epoxide oxygen trans), as well as the incorporation of