1446495-06-2

Upstream product

• 1446494-90-1 (3S,3aR,3a¹R,6aR,7S,7aR,11S,11aS,11bS)-7-hydroxy-5,5,8,8-tetramethyl-15-methylene-2,3,3a,7,7a,8,9,11b-octahydro-1H-6a,11a-(epoxymethano)-3,3a¹-ethanophenanthro[1,10-de][1,3]dioxin-14-one 
• 1446494-89-8 (3S,3aR,3a¹R,6aR,7S,7aR,11S,11aS,11bS)-7-hydroxy-5,5,8,8-tetramethyl-15-methylene-14-oxodecahydro-1H-6a,11a-(epoxymethano)-3,3a¹-ethanophenanthro[1,10-de][1,3]dioxin-11-yl methanesulfonate 
• 28957-04-2 oridonin 
• 1446495-05-1 (3S,3aR,3a¹R,6aR,7S,7aR,10S,11S,11aS,11bS)-10-azido-7,11-dihydroxy-5,5,8,8-tetramethyl-15-methylenedecahydro-1H-6a,11a-(epoxymethano)-3,3a¹-ethanophenanthro[1,10-de][1,3]dioxin-14-one 
• 536-74-3 phenylacetylene 

Downstream Products

• 1446495-08-4 (1S,2S,4aR,5S,6S,6aR,9S,11aS,11bS,14R)-1,5,6,14-tetrahydroxy-4,4-dimethyl-8-methylene-2-(4-phenyl-1H-1,2,3-triazol-1-yl)decahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7(8H)-one 

Relevant academic research and scientific papers

Overcoming synthetic challenges of oridonin a-ring structural diversification: Regio- and stereoselective installation of azides and 1,2,3-triazoles at the c-1, c-2, or c-3 position

Efficient and concise synthetic approaches have been developed for the rapid and diverse installation of azide functionalities at the C-1, C-2, or C-3 positions of oridonin (1) with highly controlled regio- and stereoselectivity, while keeping key reactive pharmacophores intact by utilizing unique preactivation strategies based on the common synthon 4. Further functionalization of these azides through click chemistry yielding triazole derivatives successfully provides access to an expanded natural scaffold-based compound library for potential anticancer agents.

ORIDONIN ANALOGS, COMPOSITIONS, AND METHODS RELATED THERETO

Certain embodiments are directed to oridonin analogs or derivatives. In aspects, the derivatives are used as anticancer or anti-inflammatory agents.