14465-44-2Relevant academic research and scientific papers
Synthesis of 1,2-Dihydro-Substituted Aniline Analogues Involving N -Phenyl-3-aza-Cope Rearrangement Using a Metal-Free Catalytic Approach
Alduhaish, Osamah,Varala, Ravi,Adil, Syed Farooq,Khan, Mujeeb,Siddiqui, Mohammed Rafiq H.,Alwarthan, Abdulrhman,Alam, M. Mujahid
, (2020/10/02)
An efficient metal-free domino reaction leading to structural/electronically divergent 1,2-dihydropyridines from easily accessible propargyl vinyl anilines via N-phenyl 3-aza-Cope sigmatropic rearrangement is reported with good to excellent yields using 1,2-dichlorobenzene as solvent under thermal conditions. Spirocyclic substitution is also tolerated under the present optimized conditions.
Titanium-mediated amination of Grignard reagents using primary and secondary amines
Barker, Timothy J.,Jarvo, Elizabeth R.
, p. 8325 - 8328 (2011/10/31)
Make it, then break it: N-chlorosuccinimide (NCS) was employed as the oxidant in the synthesis of aniline derivatives using the title transformation (see scheme). Functionalization was well tolerated on both the amine and Grignard reagent. An androgen receptor agonist and several analogues were synthesized to demonstrate the utility of this method.
Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation
Reid, Carolyn S.,Patrick, Donald A.,He, Shanshan,Fotie, Jean,Premalatha, Kokku,Tidwell, Richard R.,Wang, Michael Zhuo,Liu, Qiang,Gershkovich, Pavel,Wasan, Kishor M.,Wenzler, Tanja,Brun, Reto,Werbovetz, Karl A.
experimental part, p. 513 - 523 (2011/03/17)
Analogs of the trypanocidal lead compound 1-benzyl-1,2-dihydro-2,2,4- trimethylquinolin-6-yl acetate were prepared to extend the structure-activity relationship in this series of molecules, improve the in vivo antitrypanosomal activity of the lead, and de
