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Product FOB Price Min.Order Supply Ability Supplier
Enasidenib Mesylate ;AG-221 ;1446502-11-9
Cas No: 1446502-11-9
No Data 1 Gram 1000 Gram/Week Shanghai BetterBioChem Co., Ltd. Contact Supplier
Enasidenib manufacturer/supplier
Cas No: 1446502-11-9
No Data 1 Gram 1000 Metric Ton/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Cas No: 1446502-11-9
No Data No Data 10000 Metric Ton/Month Henan Wentao Chemical Product Co., Ltd. Contact Supplier
Enasidenib Mesylate AG-221 1446502-11-9
Cas No: 1446502-11-9
No Data 100 Milligram 100 Gram/Month Taizhou Crene Biotechnology co.ltd Contact Supplier
Cas No: 1446502-11-9
No Data 10 Gram 500 Kilogram/Week Zibo Hangyu Import&Export Co., Ltd Contact Supplier
Cas No: 1446502-11-9
No Data 1 Milligram 5 Xiamen Jenny Chemical Technology Co., Ltd. Contact Supplier
Cas No: 1446502-11-9
No Data 1 Gram 10 Metric Ton/Month Zibo Dorne chemical technology co. LTD Contact Supplier
SAGECHEM/ Enasidenib / AG-221
Cas No: 1446502-11-9
No Data No Data Metric Ton/Day SAGECHEM LIMITED Contact Supplier
Enasidenib (AG-221)
Cas No: 1446502-11-9
No Data 1 Gram 10 Kilogram/Month BOC Sciences Contact Supplier
Cas No: 1446502-11-9
No Data No Data No Data Nanjing Fred Technology Co.,Ltd. Contact Supplier

1446502-11-9 Usage


Enasidenib (1446502-11-9) is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).1? It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of αKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells.1,2? Recently approved for clinical use by the FDA.


Enasidenib is a first-in-class oral selective inhibitor of mutant IDH2 enzymes (isocitrate dehydrogenase 2), for the treatment of adults with relapsed or refractory IDH2-mutated acute myeloid leukemia.

in vitro

ag-221 was found to be able to reduce 2-hg levels by >90%, reverse in-vitro histone and dna hypermethylation, and induce differentiation in leukemia cell model as well. in addition, a dose dependent proliferative burst of the human specific cd45+ blast cells was observed by the treatment of ag-221, as measured by the expression of cd11b, cd14, cd15 and cell morphology [1].

in vivo

the efficacy of ag-221 in a primary human aml xenograft model with the idh2 r140q mutation was studied, and the results showed that ag-221 could reduce 2-hg in the plasma, bone marrow, and urine of engrafted mice potently. in addition, the treatment of ag-221 could also induce a significant and dose dependent survival benefit as demonstrated by that all mice in the high dose treatment of ag-221 survived to the end of study [1].

IC 50

~16 nm for idh2 r140q mutant


1) Yen et al. (2017), AG-221, A First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations; Cancer Discov. 7 478 2) Amatangelo et al. (2017), Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response; Blood 130 732



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier

Product name 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol

1.2 Other means of identification

Product number -
Other names 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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