1446509-58-5

Basic information

• Product Name: 2-(difluoromethyl)pyridin-4-amine
• CAS NO: 1446509-58-5
• Molecular Weight: 144.124
• Mol File: 1446509-58-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(difluoromethyl)pyridin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(difluoromethyl)pyridin-4-amine(1446509-58-5)
• EPA Substance Registry System: 2-(difluoromethyl)pyridin-4-amine(1446509-58-5)

Safety Data

• Hazardous Substances Data: 1446509-58-5(Hazardous Substances Data)

Usage

General Description

2-(difluoromethyl)pyridin-4-amine, also known as DFMPA, is a chemical compound with the molecular formula C6H5F2N3. It is a pyridine derivative with a difluoromethyl substituent at the 2-position and an amine group at the 4-position. DFMPA is a building block in organic synthesis and can be used in the development of pharmaceuticals and agrochemicals. It is also used as a reagent in chemical reactions and as a starting material for the preparation of other organic compounds. The difluoromethyl group in DFMPA makes it highly useful in medicinal chemistry due to its ability to modulate the pharmacokinetic properties of the resulting molecules. As such, DFMPA is an important compound in the field of organic and medicinal chemistry with potential applications in drug discovery and development.

Upstream product

• 1211580-54-9 4-bromo-2-(difluoromethyl)pyridine 
• 1256818-14-0 2-(difluoromethyl)isonicotinic acid 
• 1192539-75-5 2-difluoromethylisonicotinic acid ethyl ester 

Relevant articles and documents

PYRAZOLO[1,5-D][1,2,4]TRIAZINE-5(4H)-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY

The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

NOVEL PYRAZOLO PYRIMIDINE DERIVATIVES AND THEIR USE AS MALT1 INHIBITORS

The present invention describes new pyrazolo-pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein, R1 is halogen, cyano, or C1-C3alkyl optionally substituted by halogen; R2 is C1-C6alkyl optionally substituted one or more times by C1-C6alkyl, C2-C6alkenyl, hydroxyl, N,N-di-C1-C6alkyl amino, N-mono-C1-C6alkyl amino, O-Rg, Rg, phenyl, or by C1-C6alkoxy wherein said alkoxy again may optionally be substituted by C1-C6alkoxy, N,N-di-C1-C6alkyl amino, Rg or phenyl; C3-C6cycloalkyl optionally substituted by C1-C6alkyl, N,N-di-C1-C6alkyl amino or C1-C6alkoxy-C1-C6alkyl, and/or two of said optional substituents together with the atoms to which they are bound may form an annulated or spirocyclic 4 - 6 membered saturated heterocyclic ring comprising 1 - 2 O atoms; phenyl optionally substituted by C1-C6alkoxy; a 5 - 6 membered heteroaryl ring having 1 to 3 heteroatoms selected from N and O said ring being optionally substituted by C1-C6alkyl which may be optionally substituted by amino or hydroxy; Rg; or N,N-di-C1-C6alkyl amino carbonyl; and R is phenyl independently substituted two or more times by Ra, 2-pyridyl independently substituted one or more times by Rb, 3-pyridyl independently substituted one or more times by Rc, or 4-pyridyl independently substituted one or more times by Rd; which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.