1446642-63-2Relevant academic research and scientific papers
Copper-catalyzed oxidative condensation of α-oxocarboxylic acids with formamides: Synthesis of α-ketoamides
Wang, Hua,Guo, Li-Na,Duan, Xin-Hua
, p. 4573 - 4576 (2013)
A copper-catalyzed coupling of α-oxocarboxylic acids with formamides is reported. This simple method provides a practical approach toward the synthesis of α-ketoamides with a variety of functional groups. Mechanistic studies have shown that the reaction proceeded via a radical process and 13C-labeled experiments proved that the amide carbon in the products comes from the corresponding carboxylic acid, not from the DMF. is
