144665-83-8Relevant academic research and scientific papers
AZABICYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY
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, (2008/06/13)
Compounds of formula (I), and salts and prodrugs thereof STR1 wherein Q is the residue of an optionally substituted azabicyclic ring system;X represents oxa or thia;Y represents H or hydroxy;R 1 and R. sup.2 independently represent phenyl or thienyl, either of which groups may be optionally substituted by halo or trifluoromethyl;R 3, R 4 and R 5 independently represent H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl,--OR a, SCH 3, SOCH 3, SO. sub.2 CH 3,--NR a R b,--NR a COR b,--NR a CO. sub.2 R b,--CO. sub.2 R a or--CONR a R b ;R a and R. sup.b independently represent H, C 1-6 alkyl, phenyl or trifluoromethyl, are tachykinin antagonists. They and compositions thereof are therefore useful in therapy.
