144666-13-7

Upstream product

• 141521-27-9 (9S,11S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-hydroxy-2-hydroxymethyl-butyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester 
• 4435-54-5 2-Methylene-1-butanol 
• 129895-92-7 (-)-(9R,2S,2'S)-3H-9-(methoxycarbonyl)-2-(2'-ethyl-2',3'dihydroxypropyl)hexahydroindolizino<8,7-b>indole cyclohexylidene ketal 
• 121464-71-9 (R)-(2-ethoxyoxiran-2-yl)methanol 
• 141521-20-2 (R)-(-)-2-ethyl-1-(phenylthio)-2,3-propanediol 
• 141521-22-4 (R)-2-Ethyl-1,4-dioxa-spiro[4.5]decane-2-carbaldehyde 
• 141521-21-3 (R)-2-Ethyl-2-phenylsulfanylmethyl-1,4-dioxa-spiro[4.5]decane 
• 141521-25-7 (R)-2-[1-((S)-2-Ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-meth-(Z)-ylidene]-2,3,6,11-tetrahydro-1H,5H-indolizino[8,7-b]indole-11b-carboxylic acid methyl ester 
• 141521-24-6 (+)-(9R,2'S)-3-thioxo-9-(methoxycarbonyl)-2-(2'-ethyl-2',3'dihydroxypropenyl)hexahydroindolizino<8,7-b>indole cyclohexylidene ketal 
• 141521-23-5 (+)-(9R,2'S)-3-thioxo-9-(methoxycarbonyl)-2-(2'-ethyl-2',3'dihydroxypropyl)hexahydro-1-hydroxyindolizino<8,7-b>indole cyclohexylidene ketal 
• 144609-71-2 (R)-2-[((R)-2-Ethyl-1,4-dioxa-spiro[4.5]dec-2-yl)-(toluene-4-sulfonyloxy)-methyl]-3-thioxo-2,3,6,11-tetrahydro-1H,5H-indolizino[8,7-b]indole-11b-carboxylic acid methyl ester 
• 141521-26-8 (S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester 
• 141521-27-9 (9R,11S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-hydroxy-2-hydroxymethyl-butyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester 
• 15799-79-8 3-methoxy-N,N-dimethylaniline 

Downstream Products

• 141521-28-0 C₃₀H₃₉N₃O₄ 

Relevant academic research and scientific papers

Nonoxidative coupling methodology for the synthesis of the antitumor bisindole alkaloid vinblastine and a lower-half analogue: Solvent effect on the stereochemistry of the crucial C-15/C-18′ bond

The overall strategy for the synthesis of vinblastine (1) is based upon the nonoxidative cleavage of the tertiary amine (+)-18 to generate the intermediate delocalized cation 18a, which in the presence of an electron-rich aromatic nucleophile can be trapp

Stereospecific Synthesis of the Top-Half Precursor to the Antitumor Agent Vinblastine and a Simple Bisindole Analogue.

The stereospecific synthesis of a precursor to the top-half of vinblastine is described.Its non-oxidative coupling to m-methoxy-N,N-dimethylaniline provides access to the vinblastine analogue 18.