1446750-99-7

Basic information

• Product Name: 1,2-Bis(piperazin-1-yl)benzene
• Synonyms: 1,2-Bis(piperazin-1-yl)benzene;Piperazine, 1,1'-(1,2-phenylene)bis-;Vortioxetine Impurity 20;1,2-di(piperazin-1-yl)benzene
• CAS NO: 1446750-99-7
• Molecular Formula: C14H22N4
• Molecular Weight: 246.35128
• EINECS: -0
• Mol File: 1446750-99-7.mol

Chemical Properties

• Boiling Point: 432.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.089±0.06 g/cm3(Predicted)
• PKA: 9.22±0.10(Predicted)
• CAS DataBase Reference: 1,2-Bis(piperazin-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Bis(piperazin-1-yl)benzene(1446750-99-7)
• EPA Substance Registry System: 1,2-Bis(piperazin-1-yl)benzene(1446750-99-7)

Safety Data

• Hazardous Substances Data: 1446750-99-7(Hazardous Substances Data)

Usage

Uses

1,2-Di(piperazin-1-yl)benzene is an impurity of the antidepressant vortioxetine .

Upstream product

• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

Preparation method of vortioxetine hydrobromide impurity standard substance

The invention relates to the technical field of drug impurity standard substances, and discloses a preparation method of a vortioxetine hydrobromide impurity standard substance. The preparation methodcomprises the steps of S1, conducting a condensation reaction, specifically, adding o-phenylenediamine, bis(2-chloroethyl) amine hydrochloric acid and an organic solvent into a reaction flask, stirring for reflux reaction, stopping heating, stirring for cooling, adding methanol into the reaction solution, stirring for dissolution, adding diethyl ether into the reaction bottle, separating out a large amount of brown solid, filtering, transferring the solid into the reaction bottle, adding 2N sodium hydroxide solution, stirring, extracting by using ethyl acetate, collecting an organic layer, drying, filtering and concentrating to obtain a 1,2-bis(piperazin-1-yl) benzene crude product and a brown oily substance. The 1,2-bis(piperazine-1-yl) benzene preparation process is simple, short in synthesis period, low in synthesis cost and novel in refining method, is suitable for small-amount synthesis in laboratories and can also be used for large-scale production, the 1,2-bis(piperazine-1-yl)benzene content calibration method is a conventional analysis method, and the equipment is conventional equipment and is easy to realize.