1446752-53-9

Upstream product

• 1446752-47-1 benzyl ((3R,4S)-3-methoxy-2,2-dimethyl-3,4-dihydro-2H-pyran-4-yl)carbamate 
• 1446752-45-9 benzyl ((4S,5R)-6-hydroxy-5-methoxy-6-methylhept-1-en-4-yl)carbamate 
• 1309369-11-6 (3R,4S)-4-amino-3-methoxy-2-methylhept-6-en-2-ol 

Relevant academic research and scientific papers

Simplified aminocoumarin analogues as anticancer agents: Amino isosteric replacement in the noviose moiety resulted in substantial enhancement of antiproliferative activity

Simplified aminocoumarin analogues, either noviosylated or simple basic heterocycle attached 3-amido-coumarin compounds, are known to be promising anticancer agents targeting the C-terminal ATP-binding site of Hsp90. In this study, 3′-amino isosteric replacement in the noviose moiety of two known noviose containing Hsp90 C-terminal inhibitors was synthetically realized for the first time. In vitro evaluation of these compounds suggested that the introduction of a basic amino group into the noviose subunit resulted in significant improvement of their cytotoxicities.