1446770-93-9

Basic information

• Product Name: tert-butyl N-[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamate
• Synonyms: tert-butyl N-[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamate
• CAS NO: 1446770-93-9
• Molecular Weight: 289.298
• Mol File: 1446770-93-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl N-[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamate(1446770-93-9)
• EPA Substance Registry System: tert-butyl N-[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamate(1446770-93-9)

Safety Data

• Hazardous Substances Data: 1446770-93-9(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 127852-30-6 (R)-α-(m-(trifluoromethyl)phenyl)ethylamine 

Downstream Products

• 1212101-09-1 methyl[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]amine 

Relevant articles and documents

Highly Enantiospecific Borylation for Chiral α-Amino Tertiary Boronic Esters

Herein we report a highly efficient and enantiospecific borylation method to synthesize a wide range of enantiopure (>99 % ee) α-amino tertiary boronic esters. The configurationally stable α-N-Boc substituted tertiary organolithium species and pinacolborane (HBpin) underwent enantiospecific borylation at ?78 °C with the formation of a new stereogenic C?B bond. This reaction has a broad scope, enabling the synthesis of various α-amino tertiary boronic esters in excellent yields and, importantly, with universally excellent enantiospecificity (>99 % es) and complete retention of configuration.