1446789-84-9Relevant academic research and scientific papers
One-step protection-free synthesis of 3-aryl-5-hydroxyalkyl-1,2,4- oxadiazoles as building blocks
Neves Filho, Ricardo A. W.,Da Silva-Alves, Diana C. B.,Dos Anjos, Janaina V.,Srivastava, Rajendra M.
supporting information, p. 2596 - 2602 (2013/07/26)
A simple and straightforward synthesis of 3-aryl-5-hydroxyalkyl-1,2,4- oxadiazoles is described. The reaction among arylamidoximes, ethyl glycolate or ethyl lactate, and potassium carbonate in refluxing toluene afforded the desired 1,2,4-oxadiazoles in moderate to good yields. The synthesis has been accomplished in a single step, avoiding protection-deprotection protocols. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.
