1446790-67-5

Basic information

• Product Name: 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide
• Synonyms: 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide
• CAS NO: 1446790-67-5
• Molecular Weight: 387.442
• Mol File: 1446790-67-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide(1446790-67-5)
• EPA Substance Registry System: 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide(1446790-67-5)

Safety Data

• Hazardous Substances Data: 1446790-67-5(Hazardous Substances Data)

Upstream product

• 1446792-02-4 tert-butyl (1S,2R)-2-(6-carbamoyl-5-(5-chloro-6-methylpyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate 
• 1446792-09-1 6-chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide 
• 365996-30-1 tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate 
• 1446792-12-6 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5-chloro-6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide 
• 1446792-00-2 6-chloro-4-(5-chloro-6-methylpyridin-2-ylamino)pyridazine-3-carboxamide 
• 36936-23-9 2-amino-5-chloro-6-methylpyridine 
• 372118-01-9 4,6-dichloro-pyridazine-3-carboxylic acid methyl ester 
• 372118-00-8 4,6-dihydroxy-pyridazine-3-carboxylic acid methyl ester 
• 83878-89-1 2-diazo-3-oxo-pentanedioic acid dimethyl ester 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 

Relevant articles and documents

Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors

Inhibition of spleen tyrosine kinase has attracted much attention as a mechanism for the treatment of cancers and autoimmune diseases such as asthma, rheumatoid arthritis, and systemic lupus erythematous. We report the structure-guided optimization of pyridazine amide spleen tyrosine kinase inhibitors. Early representatives of this scaffold were highly potent and selective but mutagenic in an Ames assay. An approach that led to the successful identification of nonmutagenic examples, as well as further optimization to compounds with reduced cardiovascular liabilities is described. Select pharmacokinetic and in vivo efficacy data are presented.