144690-92-6

Basic information

• Product Name: Trityl olmesartan
• Synonyms: TRIPHENYL METHYL OLMESARTAN;Trityl olmesartan;TRITYL OLMESARTAN MEDOXOMIL;4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1h-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester;1H-Imidazole-5-carboxylic acid,4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester;Tritylolmesartan(ForOlmesartan);TRITYL OLMESARTAN MEDOXOMIL (99.5%);N-Triphenyl Methyl Omesartan
• CAS NO: 144690-92-6
• Molecular Formula: C₄₈H₄₄N₆O₆
• Molecular Weight: 800.89956
• EINECS: 1308068-626-2
• Product Categories: INTERMEDIATESOF;(intermediate of olmesartan);Bases & Related Reagents;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
• Mol File: 144690-92-6.mol
• Article Data: 27

Chemical Properties

• Melting Point: 104-106°C
• Boiling Point: 960 °Cat760mmHg
• Flash Point: 534.4 °C
• Appearance: off-white to white powder
• Density: 1.26 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: Refrigerator
• PKA: 13.21±0.29(Predicted)
• CAS DataBase Reference: Trityl olmesartan(CAS DataBase Reference)
• NIST Chemistry Reference: Trityl olmesartan(144690-92-6)
• EPA Substance Registry System: Trityl olmesartan(144690-92-6)

Safety Data

• Hazardous Substances Data: 144690-92-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to White Powder

Uses

Different sources of media describe the Uses of 144690-92-6 differently. You can refer to the following data:
1. Olmesartan medoxomil analog as angiotensin II antagonist.
2. Olmesartan medoxomil intermediate.
3. N-1 Trityl Olmesartan Medoxomil (Olmesartan EP Impurity D) is an olmesartan medoxomil intermediate.

InChI:InChI=1/C48H44N6O6/c1-5-17-41-49-43(47(3,4)57)42(45(55)58-31-40-32(2)59-46(56)60-40)53(41)30-33-26-28-34(29-27-33)38-24-15-16-25-39(38)44-50-51-52-54(44)48(35-18-9-6-10-19-35,36-20-11-7-12-21-36)37-22-13-8-14-23-37/h6-16,18-29,57H,5,17,30-31H2,1-4H3

Upstream product

• 936114-12-4 potassium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate 
• 80841-78-7 4-chloromethyl-5-methyl-1,3-dioxol-2-one 
• 400747-06-0 C₁₆H₁₃O₂N 
• 873-32-5 2-Chlorobenzonitrile 
• 2403-54-5 2-(4-chlorophenyl)-1,3-dioxolane 
• 1114761-92-0 lithium 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate 
• 154709-18-9 4'-hydroxymethyl-2-(N-trityl-1H-tetrazol-5-yl)biphenyl 
• 155983-56-5 5-<2-(4'-formylbiphenylyl)>-2-(triphenylmethyl)-2H-tetrazole 
• 761404-85-7 4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid 
• 168265-56-3 1-benzyl-5-(4'-methyl-[1,1'-biphenyl]-2-yl)-1H-tetrazole 
• 106-38-7 para-bromotoluene 
• 144689-23-6 ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate 
• 38612-13-4 4-bromobenzyl benzoate 
• 28386-90-5 5-benzyl-1-phenyl-1H-tetrazole 

Downstream Products

• 1227626-51-8 C₄₈H₄₂N₆O₅ 
• 144689-63-4 olmesartan medoxomil 
• 76-84-6 triphenylmethyl alcohol 

Relevant articles and documents

Preparation and purification method for triphenyl methyl olmesartan compound (I)

The present invention provides a preparation and purification method for triphenyl methyl olmesartan. The method comprises the following steps: forming a triphenyl methyl olmesartan carboxylate reaction liquid by using ethyl 4-(2-hydroxy-2-propanyl)-2-pro

Method for preparing high-purity trityl olmesartan medoxomil

The invention relates to a method for preparing high-purity trityl olmesartan medoxomil. An inorganic salt solution is adopted for cooling and crystallization. The trityl olmesartan medoxomil preparedby the method has high purity. The method avoids use of

A olmesartan medoxomil and its preparation method (by machine translation)

The invention discloses a olmesartan medoxomil and its preparation method, the present invention discloses a olmesartan medoxomil, its chemical structure is: The present invention novel method for preparation method, comprises the following steps: (1) preparing AMST - 3 C45 H44 N6 O3 ; (2) preparing C43 H39 N6 NaO3 AMST - 4; (3) preparing C48 H44 N6 O6 AMST - 6; (4) preparing olmesartan sha tanzhi thick; (5) to make the C29 H30 N6 O6 Olmesartan medoxomil. The invention separation effect is good, relatively low viscosity system, split-phase required time is short, the time is saved but also reduces energy consumption. Filtering and separating the high recovery rate, the product quality is high, the running cost is low; process without the need to add chemical, solvent solvent, not into the secondary pollution material; equipment and automatic operation, good stability, easy to realize industrial demand. (by machine translation)