144699-06-9

Basic information

• Product Name: 1,25-dihydroxy-19-norprevitamin D3
• Synonyms: 1,25-dihydroxy-19-norprevitamin D3
• CAS NO: 144699-06-9
• Molecular Formula: C₂₆H₄₂O₃
• Molecular Weight: 402.60988
• Mol File: 144699-06-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,25-dihydroxy-19-norprevitamin D3(CAS DataBase Reference)
• NIST Chemistry Reference: 1,25-dihydroxy-19-norprevitamin D3(144699-06-9)
• EPA Substance Registry System: 1,25-dihydroxy-19-norprevitamin D3(144699-06-9)

Safety Data

• Hazardous Substances Data: 144699-06-9(Hazardous Substances Data)

Usage

General Description

1,25-dihydroxy-19-norprevitamin D3 is a synthetic analogue of Vitamin D3 that has been modified to have increased potency and stability. It is a powerful regulator of calcium and phosphorus metabolism in the body and is primarily used in the treatment of conditions related to Vitamin D deficiency, such as osteoporosis and hypocalcemia. 1,25-dihydroxy-19-norprevitamin D3 acts through binding to Vitamin D receptors in the intestines, bones, and kidneys, leading to increased absorption of calcium and phosphate, as well as the regulation of bone mineralization. It also has immunomodulatory effects, and may have potential therapeutic applications in various autoimmune and inflammatory conditions. Overall, 1,25-dihydroxy-19-norprevitamin D3 is an important pharmaceutical compound with diverse physiological effects, particularly related to bone health and mineral metabolism.

Upstream product

• 144717-32-8 (R)-6-{(1R,3aR,7aR)-4-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-1-yl}-2-methyl-heptan-2-ol 
• 144699-09-2 (3S,4S,5S)-3,5-bis(tert-butyldimethylsilyloxy)-1-hydroxymethyl-4-phenoxythiocarbonyloxycyclohex-1-ene 
• 139619-80-0 (1R,6R,7R)-7-[(R)-6-(methoxymethoxy)-6-methylheptan-2-yl]-6-methylbicyclo[4.3.0]nonan-2-one 
• 134458-36-9 25-hydroxy-de-A,B-cholest-8-en-8-yl trifluoromethanesulfonate 
• 101906-40-5 methyl (3S,4S,5S)-3,5-bis(tert-butyldimethylsilyloxy)-4-phenoxythiocarbonyloxycyclohex-1-enecarboxylate 
• 101906-39-2 Methyl (3R,4R,5R)-3,5-Bis<(tert-butyl)dimethylsilyloxy>-4-hydroxycyclohex-1-ene-1-carboxylate 
• 40983-58-2 methyl shikimate 
• 262594-22-9 methyl (3S,5R)-3,5-di[(tert-butyldimethylsilyl)oxy]-cyclohex-1-enecarboxylate 
• 144699-11-6 (3S,5S)-3,5-bis(tert-butyldimethylsilyloxy)cyclohex-1-enecarbaldehyde 
• 144699-08-1 3,5-di[(tert-butyldimethylsilyl)oxy]-1-ethynylcyclohex-1-ene 
• 144699-10-5 (3S,5S)-3,5-bis(tert-butyldimethylsilyloxy)-1-hydroxymethylcyclohex-1-ene 
• 139356-33-5 (3S,5S)-3,5-bis[(tert-butyl)dimethylsilyloxy]-1-hydroxycyclohexane-1-carboxylic acid methyl ester 
• 77-95-2 D-(-)-quinic acid 
• 530147-41-2 (3R,3aR,7aR)-7-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enylethynyl]-3-((R)-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-3a-methyl-2,3,3a,4,5,7a-hexahydro-1H-indene 

Relevant articles and documents

Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1α,25-dihydroxyvitamin D analogs

A novel series of analogs of 1.25-dihydroxyvitamin D3, the hormonally active metabolite of vitamin D3, characterised by the presence of a trans-fused decalin CD-ring system, possesses surprising biological activities in combination w

Synthesis of 1α,25-Dihydroxy-19-norprevitamin D3

We describe a convergent synthesis of 1α,25-dihydroxy-19-norprevitamin D3 (3), an analogue of the hormone 1α,25-dihydroxyvitamin D3 (1c), that is locked into the previtamin form.