144702-10-3

Upstream product

• 144702-99-8 methyl 4'-[(2-n-propyl-4-methyl-6-amidino-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylate 

Relevant academic research and scientific papers

BENZIMIDAZOLES USEFUL AS ANGIOTENSIN-II ANTAGONISTS

Disclosed herein are angiotensin-II antagonists of the formula STR1 wherein R 1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R 2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R. sub. 3 is, inter alia, lower alkyl; and, R 4 is an acidic group, such as carboxyl or tetrazolyl.An exemplary compound is: (a) 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazol-1-yl]m ethyl]-biphenyl-2-carboxylic acid.