1447082-86-1Relevant articles and documents
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors
Stammers, Timothy A.,Coulombe, René,Rancourt, Jean,Thavonekham, Bounkham,Fazal, Gulrez,Goulet, Sylvie,Jakalian, Araz,Wernic, Dominic,Tsantrizos, Youla,Poupart, Marc-André,B?s, Michael,McKercher, Ginette,Thauvette, Louise,Kukolj, George,Beaulieu, Pierre L.
, p. 2585 - 2589 (2013/06/27)
A novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors were derived from a fragment-based approach using information from X-ray crystallographic analysis of NS5B-inhibitor complexes and iterative rounds of parallel synthesis. Structure-based drug design strategies led to the discovery of potent sub-micromolar inhibitors 11a-c and 12a-c from a weak-binding fragment-like structure 1 as a starting point.
