1447235-06-4

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 134804-56-1 (E)-3-(2-(benzyloxy)phenyl)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 1447235-61-1 4-(2-(benzyloxy)phenyl)-2-(4-methoxyphenyl)quinoline 
• 1447235-36-0 4-(2-(benzyloxy)phenyl)-2-(4-methoxyphenyl)-1-tosyl-1,4-dihydroquinoline 

Relevant academic research and scientific papers

Synthesis of quinolines from N-tosyl-1-azadienes

A route to aryl-substituted quinolines from N-tosyl 1-azadienes is described. The key steps are a [4 + 2] cycloaddition with benzyne followed by base treatment of the 1,4-dihydroquinoline product. The N-tosyl 1-azadienes were prepared from readily accessible cinnamaldehyde and chalcone substrates by condensation with p-TsNH2. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.