1447255-31-3

Basic information

• Product Name: 6-chloro-2-methoxy-N-(3-bromobenzyl)acridin-9-amine
• Synonyms: 6-chloro-2-methoxy-N-(3-bromobenzyl)acridin-9-amine
• CAS NO: 1447255-31-3
• Molecular Weight: 427.728
• Mol File: 1447255-31-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-methoxy-N-(3-bromobenzyl)acridin-9-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-methoxy-N-(3-bromobenzyl)acridin-9-amine(1447255-31-3)
• EPA Substance Registry System: 6-chloro-2-methoxy-N-(3-bromobenzyl)acridin-9-amine(1447255-31-3)

Safety Data

• Hazardous Substances Data: 1447255-31-3(Hazardous Substances Data)

Upstream product

• 86-38-4 6,9-dichloro-2-methoxyacridine 
• 10269-01-9 3-bromobenzylamine 
• 91-38-3 4-chloro-2-(4-methoxyphenylamino)benzoic acid 
• 104-94-9 4-methoxy-aniline 
• 50-84-0 2,4 dichlorobenzoic acid 

Relevant articles and documents

Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase i inhibitor

Multi-target agents against tyrosine kinases and topoisomerases are potentially useful for the effective treatment of cancers. Discovery of new multi-target scaffolds are important for developing such agents. A series of five novel acridine analogues, LXL 1-5, were synthesized and their antiproliferative activity against HepG-2 cell lines were evaluated, among which the 9-benzyloxyacridine analogue, LXL-5, showed inhibitory activity against tyrosine kinases, VEGFR-2 and Src. The results of UV-visible absorption spectra and fluorescence emission spectra, as well as DNA topoisomerase I inhibition assay, indicated topoisomerase I inhibitory activity. Our study suggested that acridine scaffold, previously shown to have no multi-target kinase and topoisomerase inhibitory activity, might be potentially developed as a multi-target inhibitor of tyrosine kinases and topoisomerase I.