144726-82-9Relevant academic research and scientific papers
SYNTHESIS AND STUDY OF THE STRUCTURE OF o-HYDROXYARYL-1,2,4-OXADIAZOLES
Ryabukhin, Yu. I.,Eliseeva, A. Yu.,Suzdalev, K. F.,Bulgarevich, S. B.,Movshovich, D. Ya.,et al.
, p. 454 - 463 (1992)
The reaction of 4-oxo-1,3-benz- and naphthoxazinium perchlorates with hydroxylamine leads to 5-(-o-hydroxyaryl)-1,2,4-oxadiazoles rather than to 3-(o-hydroxyaryl)-1,2,4-oxadiazoles, as was previously assumed.The structure of the compounds obtained was pro
Microwave assisted synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from substituted amidoximes and benzoyl cyanides
Kandre, Shivaji,Bhagat, Pundlik Rambhau,Sharma, Rajiv,Gupte, Amol
supporting information, p. 3526 - 3529 (2013/07/05)
We report herein the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from amidoximes and substituted or unsubstituted benzoyl cyanides under microwave irradiation. Substituted or unsubstituted O-carboxyphenyl amidoxime is a key intermediate of this alternative method developed for the synthesis of these heterocycles. These reactions employ simple synthetic protocols devoid of lengthy purification procedures and proceed with good yield.
