144741-90-2

Basic information

• Product Name: 1-(p-chlorophenyl)-1-n-butyl-2-(1,2,4-triazol-4-yl)ethanol
• Synonyms: 1-(p-chlorophenyl)-1-n-butyl-2-(1,2,4-triazol-4-yl)ethanol
• CAS NO: 144741-90-2
• Molecular Weight: 279.769
• Mol File: 144741-90-2.mol

Chemical Properties

• CAS DataBase Reference: 1-(p-chlorophenyl)-1-n-butyl-2-(1,2,4-triazol-4-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(p-chlorophenyl)-1-n-butyl-2-(1,2,4-triazol-4-yl)ethanol(144741-90-2)
• EPA Substance Registry System: 1-(p-chlorophenyl)-1-n-butyl-2-(1,2,4-triazol-4-yl)ethanol(144741-90-2)

Safety Data

• Hazardous Substances Data: 144741-90-2(Hazardous Substances Data)

Upstream product

• 25017-08-7 1-(4-chlorophenyl)pentan-1-one 
• 76674-17-4 1-(p-chlorophenyl)-1-n-butyl-2-(1,2,4-triazol-1-yl)ethanol 
• 288-88-0 1,2,4-Triazole 
• 144741-87-7 1-(p-chlorophenyl)-1-n-butyl epoxide 

Downstream Products

• 76674-17-4 1-(p-chlorophenyl)-1-n-butyl-2-(1,2,4-triazol-1-yl)ethanol 

Relevant articles and documents

Rearrangement of (1,2,4-triazol-4-yl) ethanols to (1,2,4-triazol-1-yl)ethanols

The mechanism of rearrangement of β-hydroxyethyl-(1,2,4-triazoles) has been shown using crossover experiments to be intermolecular and free energy profiles show that reactions are thermodynamically-controlled.

A GENERAL ANIONIC MECHANISM FOR THERMODYNAMIC CONTROL OF REGIOSELECTIVITY IN N-ALKYLATION AND ACYLATION OF HETEROCYCLES

Regioselective alkylation of 1,2,4-triazole (Ia,IIa) to 1-alkyl derivatives (Ib) may occur by nucleophilic displacement of the triazole anion, is thermodynamically-controlled (shown by a free energy diagram), and the position of equilibrium is relatively