1447448-27-2Relevant academic research and scientific papers
Thermal [2 + 2]-cycloaddition between silylalkynes and allenylphenols followed by the nucleophilic addition of water: Metal-free and economical synthesis of arylcyclobutenals
Ohno, Shohei,Avena, Ramon Francisco,Aoyama, Hiroshi,Fujioka, Hiromichi,Arisawa, Mitsuhiro
, p. 1220 - 1228 (2020)
Herein, we report an unprecedented thermal [2 + 2]-cycloaddition between silylalkynes and allenylphenols to form an aromatizing cyclobutachromene intermediate, followed by the nucleophilic addition of water to yield functionalized arylcyclobutenals. This reaction is atom- and pot-economical because all the atoms contained in the starting material are retained in the final product, no other reactants are required, and it proceeds in one-pot.
