1447604-65-0Relevant academic research and scientific papers
2,6-Pyridinedicarboxylic acid as organocatalyst for the synthesis of 1,5-benzodiazepines through one-pot reaction
Lal, Mohan,Basha, R. Sidick,Sarkar, Satavisha,Khan, Abu T.
, p. 4264 - 4272 (2013)
2,6-Pyridinedicarboxylic acid has been found to be an effective and efficient organocatalyst for the synthesis of 1,5-benzodiazepine derivatives from o-phenylenediamine, β-ketoesters, and aromatic aldehydes by employing one-pot three-component reaction. The catalyst plays a crucial role for the regioselective C-C bond formation at the γ position of β-ketoesters. The salient features of this present protocol are simple reaction procedure, requirement of cost-effective catalyst, good yields, and applicable to a wide range of substrates.
Facile Access to 1,5-Benzodiazepines via Amine-Promoted (4+3) Annulations of δ-Acetoxy Allenoates with o -Diaminobenzenes under Mild Conditions
Wang, Yi-Fan,He, Cheng-Yu,Hou, Longlei,Tian, Ping,Lin, Guo-Qiang,Tong, Xiaofeng
supporting information, p. 1176 - 1180 (2018/03/29)
An amine-promoted (4+3) annulation of δ-acetoxy allenoate with o -diaminobenzene is reported, providing a facile access to 1,5-benzodiazepine. This method features wide reaction scope, mild conditions, and readily available starting materials. The cascade reaction involves aza-Michael addition of o -diaminobenzene to allenoate, elimination of acetate group, and subsequent 1,6-aza-Michael addition.
Bromodimethylsulfonium bromide (BDMS)-catalyzed synthesis of 1,5-benzodiazepines using a multi-component reaction strategy
Sarkar, Satavisha,Deka, Jugal Kishore Rai,Hazra, Jagadish P.,Khan, Abu T.
supporting information, p. 2601 - 2605 (2013/12/04)
A new approach for the synthesis of multi-functionalized 15-benzodiazepines is developed starting from o-phenylenediamines, β-keto esters and aromatic aldehydes utilizing a one-pot, three-component strategy employing bromodimethylsulfonium bromide as the
