1447606-32-7

Basic information

• Product Name: N-(5-Methoxy-2-(pyridin-2-yl)pyrimidin-4-yl)-1H-indazol-6-amine
• Synonyms: N-(5-Methoxy-2-(pyridin-2-yl)pyrimidin-4-yl)-1H-indazol-6-amine
• CAS NO: 1447606-32-7
• Molecular Formula: C17H14N6O
• Molecular Weight: 318.33266
• Mol File: 1447606-32-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(5-Methoxy-2-(pyridin-2-yl)pyrimidin-4-yl)-1H-indazol-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-Methoxy-2-(pyridin-2-yl)pyrimidin-4-yl)-1H-indazol-6-amine(1447606-32-7)
• EPA Substance Registry System: N-(5-Methoxy-2-(pyridin-2-yl)pyrimidin-4-yl)-1H-indazol-6-amine(1447606-32-7)

Safety Data

• Hazardous Substances Data: 1447606-32-7(Hazardous Substances Data)

Usage

General Description

The chemical compound N-(5-Methoxy-2-(pyridin-2-yl)pyrimidin-4-yl)-1H-indazol-6-amine, also known as GDC-0339, is a potent and selective inhibitor of PI3Kα, a key enzyme involved in the regulation of cell growth, proliferation, and survival. N-(5-Methoxy-2-(pyridin-2-yl)pyrimidin-4-yl)-1H-indazol-6-amine has shown promising potential as a targeted therapy for cancer, particularly in the treatment of solid tumors with PIK3CA mutations. GDC-0339 has demonstrated inhibitory effects on the PI3K signaling pathway and has shown antitumor activity in preclinical studies. Its development as a potential anticancer agent is currently being investigated in clinical trials.