1447665-44-2Relevant academic research and scientific papers
Trifluoromethylation of ketones and aldehydes with Bu3SnCF 3
Sanhueza, Italo A.,Bonney, Karl J.,Nielsen, Mads C.,Schoenebeck, Franziska
, p. 7749 - 7753 (2013)
The (trifluoromethyl)stannane reagent, Bu3SnCF3, was found to react under CsF activation with ketones and aldehydes to the corresponding trifluoromethylated stannane ether intermediates at room temperature in high yield. Only a mildly acidic extraction (aqueous NH 4Cl) is required to release the corresponding trifluoromethyl alcohol products. The protocol is compatible with acid-sensitive functional groups.
